| Date & Time | Favorite | Spread | Underdog |
| 9/25 1:00 ET | At Cincinnati | -1.5 | San Francisco |
| 9/25 1:00 ET | New England | -7 | At Buffalo |
| 9/25 1:00 ET | At New Orleans | -3.5 | Houston |
| 9/25 1:00 ET | At Philadelphia | -8 | NY Giants |
| 9/25 1:00 ET | Miami | -1.5 | At Cleveland |
| 9/25 1:00 ET | At Tennessee | -7 | Denver |
| 9/25 1:00 ET | Detroit | -3 | At Minnesota |
| 9/25 1:00 ET | At Carolina | -3.5 | Jacksonville |
| 9/25 4:05 ET | At San Diego | -14 | KC |
| 9/25 4:05 ET | NY Jets | -2.5 | At Oakland |
| 9/25 4:05 ET | Baltimore | -5.5 | At St. Louis |
| 9/25 4:15 ET | At Tampa Bay | -1 | Atlanta |
| 9/25 4:15 ET | Arizona | -3.5 | At Seattle |
| 9/25 4:15 ET | Green Bay | -4.5 | At Chicago |
| 9/25 8:25 ET | Pittsburgh | -10.5 | At Indianapolis |
Monday Night Football Point Spread
| 9/26 8:35 ET | At Dallas | -3 | Washington |
